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Trigeminal neuralgia

MedGen UID:
21683
Concept ID:
C0040997
Disease or Syndrome
Synonyms: Disease, Fothergill; Epileptiform Neuralgia; Epileptiform Neuralgias; Fothergill Disease; Neuralgia, Epileptiform; Neuralgia, Trifacial; Neuralgia, Trigeminal; Tic Doloureux; Tic Douloureux; Trifacial Neuralgia; Trifacial Neuralgias; Trigeminal Neuralgia; Trigeminal Neuralgias
SNOMED CT: TN - Trigeminal neuralgia (31681005); Trigeminal neuralgia (31681005); Tic douloureux (31681005); Trifacial neuralgia (31681005); Fothergill's neuralgia (31681005)
Modes of inheritance:
Not genetically inherited
MedGen UID:
988794
Concept ID:
CN307044
Finding
Source: Orphanet
clinical entity without genetic inheritance.
 
HPO: HP:0100661
Monarch Initiative: MONDO:0008599
OMIM®: 190400
Orphanet: ORPHA221091

Definition

A neuropathic disorder characterized by episodes of intense pain in the face, originating from the trigeminal nerve. One, two, or all three branches of the nerve may be affected. [from HPO]

Clinical features

From HPO
Trigeminal neuralgia
MedGen UID:
21683
Concept ID:
C0040997
Disease or Syndrome
A neuropathic disorder characterized by episodes of intense pain in the face, originating from the trigeminal nerve. One, two, or all three branches of the nerve may be affected.

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVTrigeminal neuralgia
Follow this link to review classifications for Trigeminal neuralgia in Orphanet.

Conditions with this feature

Facial hemiatrophy
MedGen UID:
8761
Concept ID:
C0015458
Disease or Syndrome
Unilateral atrophy of facial tissues, including muscles, bones and skin.
Trigeminal neuralgia
MedGen UID:
21683
Concept ID:
C0040997
Disease or Syndrome
A neuropathic disorder characterized by episodes of intense pain in the face, originating from the trigeminal nerve. One, two, or all three branches of the nerve may be affected.

Professional guidelines

PubMed

Allam AK, Sharma H, Larkin MB, Viswanathan A
Neurol Clin 2023 Feb;41(1):107-121. doi: 10.1016/j.ncl.2022.09.001. PMID: 36400550
Finnerup NB, Kuner R, Jensen TS
Physiol Rev 2021 Jan 1;101(1):259-301. Epub 2020 Jun 25 doi: 10.1152/physrev.00045.2019. PMID: 32584191
Bendtsen L, Zakrzewska JM, Heinskou TB, Hodaie M, Leal PRL, Nurmikko T, Obermann M, Cruccu G, Maarbjerg S
Lancet Neurol 2020 Sep;19(9):784-796. doi: 10.1016/S1474-4422(20)30233-7. PMID: 32822636

Curated

UK NICE Clinical Guideline CG173, Neuropathic pain in adults: pharmacological management in non-specialist settings, 2020

Recent clinical studies

Etiology

Ang L, Kim HJ, Heo JW, Choi TY, Lee HW, Kim JI, Lee MS
Complement Ther Clin Pract 2023 Aug;52:101763. Epub 2023 May 2 doi: 10.1016/j.ctcp.2023.101763. PMID: 37159979
Khawaja SN, Scrivani SJ
Dent Clin North Am 2023 Jan;67(1):99-115. Epub 2022 Oct 27 doi: 10.1016/j.cden.2022.07.008. PMID: 36404084
Lambru G, Zakrzewska J, Matharu M
Pract Neurol 2021 Oct;21(5):392-402. Epub 2021 Jun 9 doi: 10.1136/practneurol-2020-002782. PMID: 34108244Free PMC Article
May A, Hoffmann J
Curr Opin Neurol 2021 Jun 1;34(3):373-377. doi: 10.1097/WCO.0000000000000927. PMID: 33661160
Di Stefano G, Maarbjerg S, Truini A
J Headache Pain 2019 Feb 19;20(1):20. doi: 10.1186/s10194-019-0969-0. PMID: 30782116Free PMC Article

Diagnosis

Khawaja SN, Scrivani SJ
Dent Clin North Am 2023 Jan;67(1):99-115. Epub 2022 Oct 27 doi: 10.1016/j.cden.2022.07.008. PMID: 36404084
Allam AK, Sharma H, Larkin MB, Viswanathan A
Neurol Clin 2023 Feb;41(1):107-121. doi: 10.1016/j.ncl.2022.09.001. PMID: 36400550
Radoš I
Acta Clin Croat 2022 Sep;61(Suppl 2):96-102. doi: 10.20471/acc.2022.61.s2.12. PMID: 36824641Free PMC Article
Bendtsen L, Zakrzewska JM, Heinskou TB, Hodaie M, Leal PRL, Nurmikko T, Obermann M, Cruccu G, Maarbjerg S
Lancet Neurol 2020 Sep;19(9):784-796. doi: 10.1016/S1474-4422(20)30233-7. PMID: 32822636
Maarbjerg S, Di Stefano G, Bendtsen L, Cruccu G
Cephalalgia 2017 Jun;37(7):648-657. Epub 2017 Jan 11 doi: 10.1177/0333102416687280. PMID: 28076964

Therapy

Ang L, Kim HJ, Heo JW, Choi TY, Lee HW, Kim JI, Lee MS
Complement Ther Clin Pract 2023 Aug;52:101763. Epub 2023 May 2 doi: 10.1016/j.ctcp.2023.101763. PMID: 37159979
Radoš I
Acta Clin Croat 2022 Sep;61(Suppl 2):96-102. doi: 10.20471/acc.2022.61.s2.12. PMID: 36824641Free PMC Article
Cruccu G, Di Stefano G, Truini A
N Engl J Med 2020 Aug 20;383(8):754-762. doi: 10.1056/NEJMra1914484. PMID: 32813951
Serrera-Figallo MA, Ruiz-de-León-Hernández G, Torres-Lagares D, Castro-Araya A, Torres-Ferrerosa O, Hernández-Pacheco E, Gutierrez-Perez JL
Toxins (Basel) 2020 Feb 11;12(2) doi: 10.3390/toxins12020112. PMID: 32053883Free PMC Article
Attal N, Cruccu G, Baron R, Haanpää M, Hansson P, Jensen TS, Nurmikko T
Eur J Neurol 2010 Sep;17(9):1113-e88. Epub 2010 Apr 9 doi: 10.1111/j.1468-1331.2010.02999.x. PMID: 20402746

Prognosis

Chandra PS
Neurol India 2022 May-Jun;70(3):843-844. doi: 10.4103/0028-3886.349723. PMID: 35864606
Martínez-Álvarez R, Martínez-Moreno N, Kusak ME, Rey-Portolés G
J Neurosurg 2014 Dec;121 Suppl:222-5. doi: 10.3171/2014.8.GKS141273. PMID: 25434956
van Hecke O, Austin SK, Khan RA, Smith BH, Torrance N
Pain 2014 Apr;155(4):654-662. Epub 2013 Nov 26 doi: 10.1016/j.pain.2013.11.013. PMID: 24291734
Hayashi M
Prog Neurol Surg 2009;22:182-190. doi: 10.1159/000163431. PMID: 18948729
Harrison MS
J Laryngol Otol 1976 Jun;90(6):561-70. doi: 10.1017/s0022215100082451. PMID: 778316

Clinical prediction guides

Anisimov ED, Rzaev JA, Moysak GI, Dmitriev AB, Duff IE, Slavin KV
Stereotact Funct Neurosurg 2023;101(6):387-394. Epub 2023 Nov 6 doi: 10.1159/000534488. PMID: 37931603
Ang L, Kim HJ, Heo JW, Choi TY, Lee HW, Kim JI, Lee MS
Complement Ther Clin Pract 2023 Aug;52:101763. Epub 2023 May 2 doi: 10.1016/j.ctcp.2023.101763. PMID: 37159979
Hong JH, Lee JY, Kim SJ, Seo KH
Pain Physician 2023 Jan;26(1):39-44. PMID: 36791292
Wolf A, Kondziolka D
Neurosurg Clin N Am 2016 Jul;27(3):297-304. doi: 10.1016/j.nec.2016.02.006. PMID: 27324996
Gurvits GE, Tan A
World J Gastroenterol 2014 Aug 21;20(31):10845-50. doi: 10.3748/wjg.v20.i31.10845. PMID: 25152586Free PMC Article

Recent systematic reviews

Truini A, Aleksovska K, Anderson CC, Attal N, Baron R, Bennett DL, Bouhassira D, Cruccu G, Eisenberg E, Enax-Krumova E, Davis KD, Di Stefano G, Finnerup NB, Garcia-Larrea L, Hanafi I, Haroutounian S, Karlsson P, Rakusa M, Rice ASC, Sachau J, Smith BH, Sommer C, Tölle T, Valls-Solé J, Veluchamy A
Eur J Neurol 2023 Aug;30(8):2177-2196. Epub 2023 May 30 doi: 10.1111/ene.15831. PMID: 37253688
Ang L, Kim HJ, Heo JW, Choi TY, Lee HW, Kim JI, Lee MS
Complement Ther Clin Pract 2023 Aug;52:101763. Epub 2023 May 2 doi: 10.1016/j.ctcp.2023.101763. PMID: 37159979
Zakrzewska JM, Linskey ME
BMJ Clin Evid 2014 Oct 6;2014 PMID: 25299564Free PMC Article
van Hecke O, Austin SK, Khan RA, Smith BH, Torrance N
Pain 2014 Apr;155(4):654-662. Epub 2013 Nov 26 doi: 10.1016/j.pain.2013.11.013. PMID: 24291734
Zakrzewska JM, Linskey ME
BMJ Clin Evid 2009 Mar 12;2009 PMID: 19445753Free PMC Article

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Curated

    • NICE, 2020
      UK NICE Clinical Guideline CG173, Neuropathic pain in adults: pharmacological management in non-specialist settings, 2020

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